Vittorio PRODI MEP (S&D, IT) invites you to:
‘Human Toxome Project’
A new European Horizon for Risk Assessment
15th of May, 12:00 to 14:00
Toxicity testing is not delivering what safety of products demands nor is it sufficiently relying upon the most advanced technologies. It typically involves studying adverse health outcomes in animals subjected to high doses of toxicants with subsequent extrapolation to expected human responses at lower doses. But we are not 70kg rats feeding largely on chemicals. The system is expensive, time-consuming, low-throughput and often provides results of limited predictive value for human health. The toxicity testing methods are largely the same for industrial chemicals, pesticides and drugs, and have led to a backlog of more than 80,000 chemicals to which humans are potentially exposed but whose potential toxicity remains largely unknown.
In the US, a new toxicity testing plan has been launched which includes the use of predictive, high-throughput cell-based assays (of human origin) to evaluate perturbations in key pathways of toxicity, and to conduct targeted testing against those pathways. Mapping the entirety of these pathways (hence the ‘Human Toxome Project’) could be a large-scale effort, perhaps on the order of the Human Genome Project. It could develop tremendous opportunities for REACH, the testing ban for cosmetics, the pesticide regulation, and the endocrine disruptor screening, while reducing animal suffering. How can Europe contribute to this goal?
12:00 Introduction by Vittorio Prodi, MEP 12:05 Prof. Thomas Hartung,
Johns Hopkins University and former head of ECVAM
(European Centre for the Validation of Alternative Methods)
12:20 Prof. Roberto Dall’ Aglio
Professor of Endocrinology
President of the Chemotherapy-Oncology clinic of the University of Milan Italy
12:30 Troy Seidle Director of Research & Toxicology
Humane Society International
12:40 Pharmaceutical industry representative- Bracco (tbc) 12:50 Q&A 13:05 Prof. Jos Kleinjans HOD
Department of Toxicogenomics
12:50 Q&A 13:15 Dr. Gernot Klotz
Executive Director Research and Innovation
The European Chemical Industry Council (CEFIC)
13:25 Mr. Philippe Martin
Head of Sector
Assessment of New Risks and Research Co-ordination DG SANCO
13:35 Dr. Roberto Bertollini (tbc)
Director World Health Organization
13:45 Q&A 13:55 Conclusions by Vittorio Prodi MEP
Working Language: English
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